Bacterial two-component systems share a common mechanism to regulate signaling and specificity
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Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 BACTERIAL TWO-COMPONENT SYSTEMS SHARE A COMMON MECHANISM TO REGULATE SIGNALING AND SPECIFICITY
منابع مشابه
A Systems Biological Approach Reveals Multiple Crosstalk Mechanism between Gram-Positive and Negative Bacterial Infections: An Insight into Core Mechanism and Unique Molecular Signatures
BACKGROUND Bacterial infections remain a major threat and a leading cause of death worldwide. Most of the bacterial infections are caused by gram-positive and negative bacteria, which are recognized by Toll-like receptor (TLR) 2 and 4, respectively. Activation of these TLRs initiates multiple pathways that subsequently lead to effective immune response. Although, both the TLRs share common sign...
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Intracellular signaling pathways that share common components often elicit distinct physiological responses. In most cases, the biochemical mechanisms responsible for this signal specificity remain poorly understood. Protein scaffolds and cross-inhibition have been proposed as strategies to prevent unwanted cross-talk. Here, we report a mechanism for signal specificity termed "kinetic insulatio...
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In recent years, fundamental questions about how cells first detect stimuli and then process the resulting information have been increasingly studied by physicists and mathematicians. Indeed, without the benefit of systematic theoretical analysis, it would be much harder to make sense of the immense complexity of cellular signaling networks. One particularly troublesome issue in cell signaling ...
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Predictive understanding of the myriads of signal transduction pathways in a cell is an outstanding challenge of systems biology. Such pathways are primarily mediated by specific but transient protein-protein interactions, which are difficult to study experimentally. In this study, we dissect the specificity of protein-protein interactions governing two-component signaling (TCS) systems ubiquit...
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تاریخ انتشار 2015